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For instance, the depletion of short-chain fatty acids (SCFAs) promotes the polarization of M1 macrophages, which drives intestinal inflammation [36]

Key safety risks include hypoglycaemia when combined with insulin or sulphonylureas, gastrointestinal interactions, pancreatitis, gallbladder disease, and dehydration-related acute kidney injury

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Upon low energy levels, AMPK can phosphorylate FOXO3 in six different residues (T179, S399, S413, S555, S588, and S626) to induce FOXO activity

NAPQI formation can be monitored indirectly through the presence of circulating paracetamol-protein adducts (PPA)