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In a post-hoc analysis of the SURPASS-4 trial, tirzepatide decreased albuminuria (protein in urine, a marker of kidney damage) and nearly halved the risk of a composite kidney endpoint compared to insulin glargine

Sndergaard and Tine A

There is no washout period required

The findings suggest infant risk due to semaglutide in milk is likely negligible, and fears about a baby being exposed to semaglutide via breast milk are likely overestimated, the authors wrote

Doctors almost always start patients on a very low dose of semaglutide for four weeks before bumping it up

Orforglipron also suppresses glucagon secretion from pancreatic -cells