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GLP-1 medications may be contraindicated if you have or have a history of: personal and family history of papillary and follicular thyroid cancers (given that there may be an increased risk based on animal studies) chronic nausea, vomiting or gastroparesis (as GLP-1s slow down gastric emptying and may worsen GI symptoms) pancreatitis (GLP-1s may increase the risk of pancreatitis or inflammation of the pancreas) children under 12 years old currently pregnant or breastfeeding eating disorders allergy or hypersensitivity to the medication weight cycling (losing and gaining weight back) without needing to lose weight for health reasons Always consult a healthcare professional before starting GLP-1 medications to ensure they align with your health needs and treatment plan
However, emerging evidence suggests a potential link between GLP-1 therapy and altered pain perception, possibly through several mechanisms: 1- Neuroinflammation and Microglial Activation: GLP-1 receptors are expressed in the brainstem, spinal cord, and dorsal root ganglia, regions involved in pain modulation
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