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The hyper-concentrated mix in Scenario 3 might be suitable for protocols requiring very large doses, but it introduces a higher margin for error with smaller dose measurements

15-th Edition (Association of official Chemists, Washington, USA, 1990) Association of Official Analytical Chemists (AOAC), (2000)

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Sertraline was shown to impair both the ligand-induced acrosome reaction and spermatozoa entry into viscous media and it almost completely inhibited the sperm-specific Ca 2+ -permeable ion channel (CatSper), with a significant inhibitory effect on prostaglandin-induced Ca 2+ influx (Figure 1)