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Gene expression: GHK-Cu has been documented to up- or downregulate over 4,000 human genes in cell-culture models, affecting pathways related to inflammation, tissue repair, and antioxidant defense (PMID 29986520)

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Conversely, on January 11, 2024, the Food and Drug Administration did not rule out a potential small risk and is conducting a meta-analysis of clinical trials and post-marketing data in the Sentinel System [181]