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& Jones, J

Data was graphed after normalizing each insulin time course by dividing by the secretion rate at each time point by the rate obtained in the presence of 20 mM glucose prior to the addition of test compounds

This peak, however, disappears upon addition of GSH

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The amount of glutathione from cells was read from a standard curve via the rate of change in the absorbance (A 412nm min 1 )

These findings suggest that retatrutide may offer broader cardiometabolic benefit beyond blood pressure reduction alone