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It is a partial sequence derived from a protein found in human gastric juice, which is one reason much of its early research focused on the gastrointestinal tract

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Benefits of GHK CU GHK-Cu or Glycyl-L-Histidyl-L-Lysine-Copper, is the most popular and well-researched copper peptide

This is a general challenge for signal peptides and is not unique to GHK-Cu