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Multivariable linear regression was also performed to determine relationships between change in body weight and changes in study outcomes with semaglutide unadjusted and after adjusting (a priori) for age, sex, NYHA functional class, history of coronary artery disease, history of atrial fibrillation, baseline CRP and baseline NTproBNP levels

But Trapps lab discovered a critical flaw: preproglucagon (PPG) neurons, which produce GLP-1 in the brainstem, lack receptors for circulating GLP-1

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[00:58:41] Michael: Yes

However, this pathway carries both opportunities and substantial risks that must be carefully navigated

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