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Pro-inflammatory mediators, such as TNF- and IL-1, enhance iron dysregulation by promoting ferritin degradation and releasing free iron into the cytosol

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Based on the federal notice and prior regulatory filings, the substances under consideration are drawn from the broader list of peptides that were placed on the Category 2 restricted list beginning in 2023

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Mounjaro was first approved by the FDA in May 2022 to treat type 2 diabetes, and Zepbound was approved by the FDA in November 2023 for long-term weight loss in adults with both obesity and either diabetes or an increased risk for a cardiovascular condition