Maybe they get healthier with some weight loss, and there may be some secondary gains, George says
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Two different drugs: sibutramine, an unspecific inhibitor of serotonin and norepinephrine reuptake, and the rimonabant, an endocannabinoid CB1 receptor antagonist, which act by reducing appetite and increasing energy expenditure, while appearing promising in subjects with PWS, have been withdrawn due to serious cardiovascular and psychiatric side effects, respectively, that emerged during clinical trials [81, 87]
PMID: 14574347 Lustig RH, Hinds PS, Ringwald-Smith K, Christensen RK, Kaste SC, Schreiber RE, Rai SN, Lensing SY, Wu S, Xiong X
(15) Collagen is of course the elastic material of skin and ligaments
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