But in practice, and especially with regard to synthetic and recombinant peptide forms, there are some considerable potential safety concerns: Immunogenicity Most notably, per a 2020 assessment on therapeutic peptide safety, synthetic and recombinant peptides pose the risk of immunogenicity the ability of a substance to provoke an immune response.15 An immunogenicity-inducing peptide, when introduced to the body, would cause the bodys immune system to perceive the peptide not as a medication but as a threat
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Large database studies examining autoimmune disease incidence and outcomes in GLP-1 receptor agonist users will continue to emerge, providing increasingly refined estimates of any protective or risk-elevating associations
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In order to extend its effectiveness, scientific researchers developed GLP-1 receptor agonists, such as exendin-4, which was initially found in the venom of the Gila monster
10.1038/npp.2014.175 Neuropsychopharmacology 35 HsuT