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Persistent hyper-ghrelinemia promotes hyperphagia and obesity later in childhood [58], even if some Authors argued against a direct role of high ghrelin levels in the hyperphagia of PWS [69]

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Throughout this review, we differentiate bioactive peptides, defined as naturally occurring or food-derived sequences that exert physiological effects, from therapeutic peptides, which are purposefully engineered pharmaceutical agents intended for clinical application

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