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Any perturbation of this balance, caused by excessive production of disulphide bonds during normal protein secretion or the production of mutant misfolded protein, might cause an excess of ROS to accumulate and ultimately lead to cell death

Its exact mechanism of action is not fully understood, but it is thought to work primarily through central inhibition of cyclooxygenase enzymes and other central nervous system pathways, reducing prostaglandin synthesis and thereby lowering pain perception and body temperature

& Rhodes, L

The concept of osmotic control of the BBB was also based on electron microscope studies, in which it was shown that the nuclei of ECs seemed to have a contracted, raisin-like appearance after exposure to histamine

& Lee, B.-C

Adv Nephrol Necker Hosp 1998