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All randomly assigned patients that were exposed to a minimum of one dose of trial product obtained while on treatment for the safety population

Our research team have also shown that insulin-stimulated increases in MBF can occur independent of changes in macrovascular blood flow but changes in MBF are rapid, and therefore MBF may facilitate the early increase in glucose uptake [4, 26]

Calcium imaging Co-cultures of ND neurons and GLUTag cells were loaded with 5 M Fura-2-acetoxymethyl ester (Molecular Probes) for 30 min in standard saline and Fura-2 calcium imaging was performed with an inverted fluorescence microscope (Olympus IX71, UK) with a 40 oil-immersion objective, coupled to a 75 W xenon arc lamp and a monochromator (Cairn Research, Faversham, UK) controlled by MetaFluor software (Molecular Devices, UK)