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FOXO4-DRIs intracellular effects persist for 4872 hours once the FOXO4p53 interaction is disrupted, even though the peptides circulating half-life is only 24 hours

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Our preclinical studies demonstrate that genetic ablation of RHAMM attenuates obesity-induced TSH elevation, mitigates hepatic oxidative stress, and modulates key metabolic signaling pathways in male mice