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As NADPH is crucial for antioxidant pathways, such as glutathione and thioredoxin, ME1 upregulation suggests enhanced cellular capacity for ROS

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Cabou C, Campistron G, Marsollier N, Leloup C, Cruciani-Guglielmacci C, Penicaud L, Drucker DJ, Magnan C, Burcelin R: Brain glucagon-like peptide-1 regulates arterial blood flow, heart rate, and insulin sensitivity

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In this subpopulation, at baseline, 85% of patients were treated with ACE inhibitor or ARB, 79% with statins, and 48% with antiplatelet agents