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It is reported that in the Phase I study assessing the safety, tolerability, pharmacokinetics, and pharmacodynamics of the drug, 98 patients with type 2 diabetes who had been continuously taking metformin were randomly assigned to receive either a placebo or PF-06882961

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Lipid peroxidation is caused by free radicals that attack unsaturated fatty acids of membranes producing lipid peroxides

It is also important to consider the use of compounded medications