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Preclinical and clinical applications of NAD + -modulating interventions for mitochondrial homeostasis and health benefits NAD + levels and mitochondrial homeostasis have been linked to symptoms of aging as well as other pathologies, including cancer, progressive muscle diseases, and neurodegenerative diseases

Volpato S, Pahor M, Ferrucci L, Simonsick EM, Guralnik JM, Kritchevsky SB, Fellin R, Harris TB (2004) Relationship of alcohol intake with inflammatory markers and plasminogen activator inhibitor-1 in well-functioning older adults: the health, aging, and body composition study

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MATERIALS AND METHODS Investigational products The products include methylcobalamin (250 g/spray) nasal spray (NASO B12