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These findings were confirmed by a Cox proportional hazards regression analysis where a 2-fold increase in either MDA max or Fe c on the corresponding day a patient reached MDA max resulted in an increase of the daily hazard of death of respectively 90 and 40%, after adjustment for age and SOFA score (Supplementary Fig

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doi: 10.1016/j.jdiacomp.2017.05.013 51 Moschovaki FilippidouFKirschAHThelenMKtszeriMArtingerKAringerIet al