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C.WangC

Stress itself typically does not cause melena, but it may exacerbate underlying conditions such as gastritis or ulcers that can lead to bleeding

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Horton says

More importantly, our results showed elevated histamine-filled MCs in the human ischemic brain during the acute and sub-acute phase of stroke, whereas in chronic stroke, MC were devoid of granules suggesting an early response of histamine in the activation of pro-inflammatory signals after stroke

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