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Once semaglutide is stopped, the biological effects of the drug begin to fade

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Though the mechanisms through which this drug might influence alcohol craving and consumption are not known, in theory semaglutides inhibition of the appetitive centers in the brain could lead to reduced cravings and appetite for things other than food, like alcohol and other drugs

This long half-life means the medication builds up gradually in your system over 4 to 5 weeks until it reaches steady state

L., Laugesen, E., & Poulsen, P