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PMC Mechanism)

It is studied for its relationship with inflammatory-response signaling, epithelial tissue models, immune pathway communication, and barrier-function research

Penninga, P.C

Zhao et al, 2004)

Compounds like synephrine and octopamine in bitter orange can cause HTN and arrhythmias, which may lead to severe CV events such as heart attack, stroke, and death

Vagotomy in animal studies is said to disrupt the transfer of -synuclein derived from the gut to the CNS, but human observational evidence is inconsistent, with some studies indicating no change in PD incidence and others suggesting a reduced risk following truncal vagotomy (Elfil et al., 2020)