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As mentioned in the Introduction, we have previously postulated that defective MIEAP expression and increased mitochondrial biogenesis which compensates impaired mitochondrial function are necessary for mitochondrial accumulation ( Braf thyrV600E ,Atg5 thyrKO/KO and Braf thyrV600E ,Mieap KO/KO mice in this study

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It comes before menopause, when menstrual periods stop