Our results align with previous studies showing that caffeine increases BDNF expression in the hippocampus (Sallaberry et al
Currently, the research aims to extend the therapy with IBATs to other pathologies, such as Alagille syndrome [103]
Notably, miRNAs influence oocyte development and follicular growth by regulating ovarian steroidogenesis, cell proliferation, and apoptosis, positioning them as potential biomarkers for assessing ovulatory dysfunction in PCOS (97)
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Therefore, the GLP-1-induced excitation of MCs, probably via inhibition of voltage-dependent potassium channel conductance and enhancement of glutamatergic neurotransmission, could lead to changed excitability of higher olfactory cortical as well as hypothalamic regions to change metabolic states
This shift is underscored by recent findings that highlight the central role of context-dependent efficacy, whereby baseline nutrient status, genetic variability, and comorbid metabolic profiles critically determine clinical outcomes (Table 1
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