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In recent years, awareness of GLP-1 medications has increased significantly as new therapies have demonstrated meaningful clinical benefits across multiple patient populations

For patients with markedly reduced GPX4 expression, antioxidants like NAC could enhance antioxidant capacity and delay disease progression

Tirzepatide efficacy Currently, tirzepatide is the most potent weight loss therapy

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Oxidative stress disrupts cellular metabolism, impedes oligodendrocyte progenitor differentiation, and limits remyelination (Spaas et al., 2021)

Among these, GLORY-1, DREAMS-1, and DREAMS-2 have already met their primary endpoints and the other four studies are currently ongoing