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Safety Profile Retatrutide is a triple receptor agonist now being investigated for obesity, T2DM, and non-alcoholic fatty liver disease

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In the GLP-1 RA cohort, the risk of DKA remained broadly constant, whilst the risk of DKA within the SGLT2i cohort increased with time and the difference in risk became statistically significant at year 5

Check blood glucose more often during 48 to 72 hours post-discontinuation in these populations, and consider earlier re-titration if necessary depending on glucose trends and clinical condition

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