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(2) Long-acting GLP-1 receptor agonist: This class of receptor agonists is characterized by consistently high drug concentrations that fall within a range that allows for substantial GLP-1 receptor stimulation with negligible inter-injection variations

clinical application of any compound for a defined medical condition belongs in the licensed clinical setting under appropriate medical supervision

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Physiol Behav (1995) 58:1197202

CRISPR-Cas9-mediated genetic knockdown (KD) of GLP1R To generate CRISPR/Cas9-mediated GLP1R-KD cell lines, single guide RNAs (sgRNAs) targeting GLP1R were designed using the Integrated DNA Technologies (IDT) CRISPR design tool and validated using CHOPCHOP ( (Supplemental Figure S1)