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The peptides ability to influence melatonin release has also been documented, providing a mechanistic link between DSIP and circadian rhythm regulation that complements its direct effects on sleep architecture

Dopamine transporters are phosphorylated on N-terminal serines in rat striatum

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As a result, the Sp- park 13 flies presented healthier mitochondria sustaining higher membrane potential, as suggested by increased TMRE staining (Fig

Animal studies have validated these hypotheses: abnormal activation of NLRP3 inflammasomes can drive excessive intestinal inflammatory responses, while functional defects in NLRP3 in intestinal epithelial cells or immune cells may impair the clearance of oral migratory bacteria, exacerbating colitis (Luo et al., 2023)