In clinical trials, people taking the 25mg daily Wegovy pill lost between 14% and 17% of their body weight over 64 weeks, depending on adherence
Secondary endpoints included change in BMI, HbA1c, lipid profile, hs-CRP, and liver enzymes
The typical dosing schedule involves: Starting with a 2.5 mg weekly injection
Research published in the New England Journal of Medicine, involving 1,961 overweight obese adults without type 2 diabetes, found that while those given a placebo in addition to lifestyle interventions lost an average of 2.6kg over the course of the 68-week study, those given a weekly injection with semaglutide alongside lifestyle interventions lost 15.3kg on average
1.7 mg/0.75 mL
Suboptimal response to semaglutide warrants systematic evaluation to identify contributing factors and guide management decisions