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Semaglutide (Wegovy/Ozempic, Novo Nordisk) and liraglutide (Saxenda, Novo Nordisk) made up 31.4% and 35.3% of all new GLP-1 receptor agonist prescriptions in 2019, respectively

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Mechanisms of Action Semaglutide: Primarily suppresses appetite, slows gastric emptying, and improves glucose regulation through GLP-1 activity

Management includes: Small, protein-focused meals Avoiding high-fat foods during escalation Adequate hydration Proactive constipation management Slower dose progression What should GPs do if weight loss plateaus