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In parallel, advances in peptide chemistry and structural biology have enabled the design of aggregation inhibitors, receptor-selective neuropeptide analogues, and cell-penetrating or brain-targeted peptide conjugates that modulate key pathways, including proteostasis, insulin and incretin signaling, neurotrophic support, and microglial activation

Serious adverse effects are rare in clinical trials

Since no significant trauma was involved in this study, only a brief muscle twitch (restricted to the stimulated limb) was expected

One worth paying attention to is nutritional depletion

doi: 10.1007/s11682-018-0029-4 15 DouaudGLeeSAlfaro-AlmagroFArthoferCWangCYMcCarthyPet al

A systematic review and meta-analysis of overweight and obese patients showed modest weight loss of 510% led to reduction in LDL-C of 0.20 mmol/dL (8 mg/dL) and triglycerides by 0.13 mmol (12 mg/dL) as well as substantial reduction in blood pressure, fasting plasma glucose, and hemoglobin A1c [26]