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Male Sprague-Dawley rats were used for behavioral testing, with 24-month-old rats of mixed sex also included for aged rat models

Older adults or those with arthritis who struggle with exercise may also benefit from starting with medication-only approaches, then gradually introducing movement as weight decreases and joint stress lessens

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8- to 12-week-old regular chowfed (RC-fed) WT mice were fasted for 56 hours and then given oral administration of water or gut-selective (14 g/mouse) or systemic (10 mg/kg) doses of sitagliptin at time 30 minutes

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