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sativa key compound, counteract the perivascular cuffing and the mononuclear cells infiltration in the brain and spinal cord, increase the red blood cells glutathione (GSH), and inhibit the NF-kB activation in EAE rat brain and spinal cord, in accord with the clinical sign improvement, decrease the number of reactive astrocytes, the proliferation of the microglial cells and stimulate the complete remyelination detected by brain ultrastructural examination (Mohamed et al., 2005)

Second, and perhaps more useful as drug evaluation tools, are ERPs

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Differential effects of IGF-binding proteins, IGFBP-3 and IGFBP-5, on IGF-I action and binding to cell membranes of immortalized human chondrocytes