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Collectively, by maintaining a reduced intracellular environment, GSH restrains pro-necrotic kinase activation and preserves inhibitory protease function, particularly CASP8, thereby preventing aberrant necroptotic signaling and inflammatory cell death

The HPA axis includes the Hypothalamus (brain region), Pituitary (a gland in the brain), and Adrenals (produces adrenalin and cortisol)

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