It protects the body against UV radiation, mechanical damage, xenobiotics, and microorganisms, and it is highly susceptible to oxidative damage (149)
Combining hesperidin with absorption enhancers such as piperine or quercetin may improve its absorption by inhibiting efflux transporters and increasing intestinal permeability [35,85]
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This increased bioavailability of 2S-hesperidine was attributed to greater formation of hesperidin catabolites, underscoring the importance of the presence of the 2S-diastereoisomer in improving hesperidin absorption efficiency
Studies report that curcumin increases glutathione S-transferase (GST) activity in the liver
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