The hormone slows gastric emptying, prolonging the feeling of fullness after meals, and acts on appetite centres in the brain to reduce food intake
Recent Neuron and Cell publications improve this concept by showing that specific shortened -synuclein species (e.g., N103) and co-pathologies (tau fragments) transmit more effectively along vagal pathways, accelerating central disease in elderly mice [130]
The 2-oxoacid dehydrogenase complexes in mitochondria can produce superoxide/hydrogen peroxide at much higher rates than complex I
They are pushing patients and doctors toward the drugs specifically approved for that purpose, like Wegovy and Zepbound, which have their own set of formidable hurdles
The STEP 1 trial showed participants lost an average of 14.9% of their body weight over 68 weeks at the 2.4mg dose
Importantly, in conditions where the affected tissue is directly involved in disease pathogenesis and can be easily obtained via minimally invasive biopsy, the power of this strategy increases substantially