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This study revealed a decrease in nitrogen metabolism, glycine and serine metabolism, gluconeogenesis, the oxidation of branched-chain fatty acids, and phytanic acid peroxisomal oxidation, phenylalanine-tyrosine metabolism, and tyrosine metabolism, indicating mitochondrial damage

As a result, in individuals with renal dysfunction, where accurate assessment of endogenous insulin secretion is challenging, a glucagon stimulation test is recommended

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Third, obesity has a strong correlation with depression, and people with obesity may be more often prescribed GLP-1RAs