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Vitamin D: modulatory effects on the aging immune system Among numerous pleiotropic physiological effects, calcitriol and its structural analogues are known to play a downright important role concerning immune reactions which have been described in an epidemiologic context correlating low vitamin D status and the occurrence of autoimmune as well as inflammatory diseases including, for example, Hashimoto thyroiditis, multiple sclerosis or inflammatory bowel disease, with higher prevalences in northern countries with decreased vitamin D synthesis [147, 158,159,160]

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