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doi: 10.3389/fphar.2021.643641 Received 14 January 2021 Accepted 14 April 2021 Published 20 May 2021 Volume 12 - 2021 Edited by Ulf Simonsen, Aarhus University, Denmark Reviewed by Eric Chung, Consultant, Brisbane, Qld, Australia Nunzia Caporarello, Mayo Clinic, United States Updates Copyright 2021 Zhang, Qin and Yuan