1 The SUSTAIN-2 trial demonstrated that adding semaglutide to metformin reduced HbA1c by 1.3-1.6% and led to weight loss of 4.3-6.1 kg over 56 weeks, compared to just 0.5% HbA1c reduction and 1.9 kg weight loss with sitagliptin added to metformin
As for your diet, you can expect significant changes to your appetite and food preferences, especially if youre also managing side effects
They are simple starting points you can adjust based on your medication, symptoms, calorie needs, and medical advice
In Katzung, B
They evaluated 3.7 million patients with diabetes and found roughly 2,500 cases of thyroid cancer
GLP-1 receptor agonists and the dual agonist tirzepatide modulate appetite, satiety, and gastric emptying, with evidence from STEP (NEJM 2021), SURMOUNT (NEJM 2022), and SURMOUNT-OSA (NEJM 2024)