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Finally, CGA was injected into Kunming (KM) mice via the tail vein for acute toxicity testing

Importantly, the role of PKA in activating multiple downstream targets involved in prosurvival signaling (eNOS, AKT) is well established (4, 21, 5054)

NAC helps the body produce glutathione naturally, which is essential for liver detox pathways, while oral glutathione supplements provide the antioxidant directly

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Moreover, cell experiments have revealed that -MSH influences the production of immunoglobulin E (IgE) and nitric oxide (NO) and inhibits IL-1-induced production of IL-8, growth-regulated protein (Gro), and nuclear factor kappa-light-chain-enhancer of activated B cells (NFB) [47, 48]

RGD-GHK also enhanced the COL-1 mRNA level, which encodes collagen type I, as shown in Figure 5D