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This indicates a strong need for better understanding of the tumor response to the treatment to overcome treatment resistance and reduce tumor progression, as well as to identify therapeutic selectivity, increasing the treatment sensitivity of the tumor while reducing adverse effects in normal tissue [1]

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The basic principle causing the radiation-induced toxicity is the excessive generation of reactive oxygen species (ROS) due to the radiolysis of cellular water, which in turn oxidizes the critical biomolecules such as lipid, protein, and DNA [36,37,38,39]