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Synthetic peptides are engineered to improve bioavailability, target selectivity, and half-life, often surpassing the pharmacokinetic limitations of natural peptides. Vlieghe et al., Drug Discovery Today Do Natural and Synthetic Peptides Have Different Clearance Times

Best practice: Match the peptide to the specific tissue damage (Vascular/Gut/Tendons = BPC-157, Structural/Muscle/Skin = TB-500), or evaluate them together for comprehensive healing

Contamination Risks: Unregulated production increases the chance of contamination with harmful substances

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Additionally, GPx1 overexpression protected against cell death and decreased infiltration of inflammatory cells in the MCAO model [107]

Efficacy and safety of berberine for dyslipidaemias: a systematic review and meta-analysis of randomized clinical trials