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This downregulation leads to smitochondrial dysfunction and activation of the adenosine receptor A2A (Adora2a)/Ras-associated protein 1 (Rap1) signaling pathway, thereby inducing VSMC ferroptosis and ultimately exacerbating vascular calcification [25]

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Experimental approaches include behavioral testing (Morris water maze, novel object recognition), electrophysiology (LTP recording), neurochemical analysis, imaging techniques (PET, MRI), and various neurotoxin or transgenic disease models

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