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(Given the potential long-term consequences of NMOSD relapses, the company could not ethically include a direct placebo arm in its Phase III trial.) Ultomiris was well-tolerated overall, and most treatment-emergent events were mild or moderate in severity, according to AstraZeneca
Rubino FM
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91,92,93 Therefore, along with bulk compressive mechanical properties, any cartilage replacement should minimize friction and maximize shear resistance to prevent wear or implant dislodgement
Routine monitoring of renal function and electrolytes is essential in this population