Fewer than 5% of clinical trial participants discontinued treatment specifically due to GI adverse events, suggesting that the vast majority found their symptoms tolerable over time
"There's nothing in the current evidence that raises unique safety red flags" beyond the known GLP-1 side effects and risks, says Srivastava
Lingvay I, Hansen T, Macura S, Marre M, Nauck MA, de la Rosa R, et al
It is a lot in absolute terms, but it is not experimental or dangerous
Mechanism of Action: Semaglutide, the active ingredient in Rybelsus, is a GLP-1 receptor agonist that mimics the natural hormone GLP-1. It works by increasing insulin secretion, decreasing glucagon secretion, and slowing gastric emptying
Amnesteem, Absorica, Claravis, Myorisan, Zenatane (isotretinoin): Used for acne, requires a 1-month deferral