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Gastrointestinal symptoms such as abdominal pain and diarrhoea secondary to colitis are classic ipilimumab-related irAEs that manifest as loose stool, abdominal pain, haematochezia and fever

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Recovery time from B12 deficiency varies depending on the severity and underlying cause

In contrast, both ORI@Lipo and ORI@CPD-Lipo exhibited sustained release profiles, with cumulative release rates of (23.84 1.02)% and (25.15 1.52)%, respectively, after 48 h

The most significant interactions are detailed below

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