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The arginate version simplifies this process, allowing researchers to prepare solutions that remain viable for longer, ensuring the dose on day 30 is just as potent as the dose on day 1

NQO1, NAD(P)H Quinone Dehydrogenase 1

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also identified as SOD3)

Analogues 1 and 2 exhibited superior potency (IC 50 = 0.30 and 0.94 M, respectively), up to 90 times more selective for AKR1C3 over AKR1C2, and demonstrated higher efficacy than indomethacin without off-target effects on AKR1C2 and COX1/2 ( 6.1.3 N-phenylanthranilic acids Among the compounds explored as AKR1C3 inhibitors, Flufenamic acid (FLU), a sort of NSAIDs, has demonstrated potent inhibition of AKR1C3 activity (IC 50 = 8.63 M)