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High fat diet increases hippocampal oxidative stress and cognitive impairment in aged mice: implications for decreased Nrf2 signaling

it has been found to reversibly inhibit complex I and mitigate ROS production associated with reverse electron transport (RET)

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Zingg JM

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The six-transmembrane epithelial antigen of prostate 3 (STEAP3) and divalent metal transporter 1 (DMT1) are involved in this process (Ohgami et al., 2005)