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For instance, glutathione requires other cofactors and processes along the methylation pathway and must pass through the liver to be activated for use

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ClinicalTrials.gov (2008)

Geier, A clinical trial of combined anti-androgen and anti-heavy metal therapy in autistic disorders

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10 NAC and sulfur amino acids Ive written before about the CBS family of genes and how certain SNPs in those pathways can affect sulfur metabolism